UR Faculty: Heinrich Jasper

UR Faculty: Heinrich Jasper: "Heinrich Jasper
Assistant Professor " U N I V E R S I T Y O F R O C H E S T E R

Gene regulation and DNA damage in the ageing human brain.

Entrez PubMed: "Nature. 2004 Jun 24;429(6994):883-91. Epub 2004 Jun 9. Related Articles, Links
Click here to read
Gene regulation and DNA damage in the ageing human brain.

Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA.

Department of Neurology and Division of Neuroscience, The Children's Hospital and Harvard Medical School, Enders 260,300 Longwood Avenue, Boston, Massachusetts 02115, USA."

Neurobiology and Neuroendocrinology of Aging

Neurobiology and Neuroendocrinology of Aging

Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells

ARTICLES
Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding
proteins in primary cultures of prostate epithelial cells

P Cohen, DM Peehl, G Lamson and RG Rosenfeld
Department of Pediatrics, Stanford University Medical Center, California 94305.

J Clin Endocrinol MetabHome page
E. S. Grant, M. B. Ross, S. Ballard, A. Naylor, and F. K. Habib
The Insulin-Like Growth Factor Type I Receptor Stimulates Growth and
Suppresses Apoptosis in Prostatic Stromal Cells
J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3252 - 3257.
[Abstract] [Full Text]

readme

EMBO Reports ageing

EMBO Reports

Ageing papers insulin readme

1: Wang MC, Bohmann D, Jasper H. Related Articles, Links
Abstract JNK extends life span and limits growth by antagonizing
cellular and organism-wide responses to insulin signaling.
Cell. 2005 Apr 8;121(1):115-25.
PMID: 15820683 [PubMed - indexed for MEDLINE]

2: van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW,
Zwaan BJ, Slagboom PE, Westendorp RG. Related Articles, Links
Abstract Reduced insulin/IGF-1 signalling and human longevity.
Aging Cell. 2005 Apr;4(2):79-85.
PMID: 15771611 [PubMed - indexed for MEDLINE]

12: Ceddia RB, Bikopoulos GJ, Hilliker AJ, Sweeney G. Related Articles, Links
Abstract Insulin stimulates glucose metabolism via the pentose
phosphate pathway in Drosophila Kc cells.
FEBS Lett. 2003 Dec 4;555(2):307-10.
PMID: 14644433 [PubMed - indexed for MEDLINE]

Nyquist Frequency -- From MathWorld

Nyquist Frequency -- From MathWorld: "In order to recover all Fourier components of a periodic waveform, it is necessary to sample more than twice as fast as the highest waveform frequency nu. So if nu is the sampling rate, the Nyquist frequency, also called the Nyquist limit, is the highest frequency that can be coded at a given sampling rate in order to be able to fully reconstruct the signal, i.e.,
f_(Nyquist)==1/2nu."

COVASIAM: an Image Analysis Method That Allows Detection of Confluent Microbial Colonies and Colonies of Various Sizes for Automated Counting

how spot counting worksCOVASIAM: an Image Analysis Method That Allows Detection of Confluent Microbial Colonies and Colonies of Various Sizes for Automated Counting: "COVASIAM: an Image Analysis Method That Allows Detection of Confluent Microbial Colonies and Colonies of Various Sizes for Automated Counting

G. Corkidi,1* R. Diaz-Uribe,1 J. L. Folch-Mallol,2 and J. Nieto-Sotelo2
Laboratorio de Procesamiento de Im�genes, Centro de Instrumentos, UNAM, M�xico Distrito Federal,1 and Departamento de Biolog�a Molecular de Plantas, Instituto de Biotecnolog�a, UNAM, Cuernavaca, Morelos,2 Mexico

*Corresponding author. Mailing address: Instituto de Biotecnolog�a, UNAM, P.O. Box 510-3, 62250 Cuernavaca, Morelos, M�xico. Phone: (5273) 11-49-00, ext 313. Fax: (5273) 80-10-20. E-mail: corkidi@sgima.ibt.unam.mx.

Received October 31, 1997; Accepted January 16, 1998."

A protein interaction map of Drosophila melanogaster.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14605208
Science. 2003 Dec 5;302(5651):1727-36. Epub 2003 Nov 6. Related Articles, Links
Click here to read
A protein interaction map of Drosophila melanogaster.

Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hao YL, Ooi CE, Godwin B, Vitols E, Vijayadamodar G, Pochart P, Machineni H, Welsh M, Kong Y, Zerhusen B, Malcolm R, Varrone Z, Collis A, Minto M, Burgess S, McDaniel L, Stimpson E, Spriggs F, Williams J, Neurath K, Ioime N, Agee M, Voss E, Furtak K, Renzulli R, Aanensen N, Carrolla S, Bickelhaupt E, Lazovatsky Y, DaSilva A, Zhong J, Stanyon CA, Finley RL Jr, White KP, Braverman M, Jarvie T, Gold S, Leach M, Knight J, Shimkets RA, McKenna MP, Chant J, Rothberg JM.

CuraGen Corporation, 555 Long Wharf Drive, New Haven, CT 06511, USA.

Drosophila melanogaster is a proven model system for many aspects of human biology. Here we present a two-hybrid-based protein-interaction map of the fly proteome. A total of 10,623 predicted transcripts were isolated and screened against standard and normalized complementary DNA libraries to produce a draft map of 7048 proteins and 20,405 interactions. A computational method of rating two-hybrid interaction confidence was developed to refine this draft map to a higher confidence map of 4679 proteins and 4780 interactions. Statistical modeling of the network showed two levels of organization: a short-range organization, presumably corresponding to multiprotein complexes, and a more global organization, presumably corresponding to intercomplex connections. The network recapitulated known pathways, extended pathways, and uncovered previously unknown pathway components. This map serves as a starting point for a systems biology modeling of multicellular organisms, including humans.

PMID: 14605208 [PubMed - indexed for MEDLINE]

Does food restriction retard aging by reducing the metabolic rate? -- McCarter et al. 248 (4): 488 -- AJP - Endocrinology and Metabolism

Does food restriction retard aging by reducing the metabolic rate? -- McCarter et al. 248 (4): 488 -- AJP - Endocrinology and Metabolism: "Does food restriction retard aging by reducing the metabolic rate?

R. McCarter, E. J. Masoro and B. P. Yu

Metabolic rate was determined by measuring O2 consumption in two groups of 6-mo-old male rats fed ad libitum (group 1) or maintained on a life-prolonging food-restriction regimen for 4.5 mo (group 2). These measurements were made continuously for 23.75 h under conditions nearly identical to those of the daily life of the rats. The metabolic rate per kilogram lean body mass was the same for both groups, a finding contrary to the hypothesis that food restriction retards the aging process and prolongs life by slowing the metabolic rate per unit of metabolic mass. This and our previous work strongly suggest that the classic views of the action of food restriction on aging must be re-evaluated because retardation of the aging process can occur without the restriction of calories or any other nutrient per unit of lean body mass. The long held belief that reducing food intake lowers the metabolic rate per unit of metabolic mass may be true in short-term dietary programs but appears not to be true when a significant portion of the life span is involved. "